H2-Gamendazole
Catalog No: 24145
CAS Number: 877768-84-8
Purity: 98% Min.
H2-Gamendazole is a derivative of Lonidamine that reduces cyst formation in polycystic kidney disease and is used in autosomal dominant polycystic kidney disease research.
For research use only. We do not sell to patients.
Chemical Information
| Name | H2-Gamendazole |
|---|---|
| Iupac Chemical Name | 3-(1-(2,4-dichlorobenzyl)-6-(trifluoromethyl)-1H-indazol-3-yl)propanoic acid |
| Synonyms | H2-Gamendazole; H2Gamendazole; H2 Gamendazole |
| Molecular Formula | C18H13Cl2F3N2O2 |
| Molecular Weight | 417.21 |
| Smile | O=C(CCC1=NN(CC2=CC=C(C=C2Cl)Cl)C3=C1C=CC(C(F)(F)F)=C3)O |
| InChiKey | OMVYOEVUBVQVKZ-UHFFFAOYSA-N |
| InChi | InChI=1S/C18H13Cl2F3N2O2/c19-12-3-1-10(14(20)8-12)9-25-16-7-11(18(21,22)23)2-4-13(16)15(24-25)5-6-17(26)27/h1-4,7-8H,5-6,9H2,(H,26,27) |
| CAS Number | 877768-84-8 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | 类白色固体 |
|---|---|
| Purity | 98% Min. |
| Storage | 0-4℃，可保存几天到几周；-20℃，可保存 几个月。 |
| Solubility | 溶于DMSO等有机溶剂 |
| Handling | |
| Shipping Condition | 可以在室温下进行运输。 |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Sundar SV, Zhou JX, Magenheimer BS, Reif GA, Wallace DP, Georg GI, Jakkaraj SR, Tash JS, Yu ASL, Li X, Calvet JP. The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease. Am J Physiol Renal Physiol. 2022 Oct 1;323(4):F492-F506. doi: 10.1152/ajprenal.00095.2022. Epub 2022 Aug 18. PMID: 35979967; PMCID: PMC9529276.
Chemical Structure
