Gridegalutamide
Catalog No: 25138
CAS Number: 2446928-30-7
Purity: 98% Min.
Gridegalutamide, also known as BMS-986365 and CC-94676, is a heterobifunctional, first-in-class, orally bioavailable AR LDD designed to induce rapid, sustained, and highly selective AR degradation in patients who progressed on standard-of-care therapies. AR degrader CC-94676 causes degradation of AR, prevents AR-mediated signaling and inhibits the proliferation of AR-overexpressing tumor cells. AR plays a key role in tumor cell proliferation in castration-resistant prostate cancer (CRPC).
For research use only. We do not sell to patients.
Chemical Information
| Name | Gridegalutamide |
|---|---|
| Iupac Chemical Name | (2R)-4-[2-[4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-ethylphenoxy]ethyl]-N-[3-[(2,6-dioxo-3-piperidinyl)amino]phenyl]-2-methyl-1-piperazineacetamide |
| Synonyms | CC-94676, CC94676; CC 94676; BMS-986365; BMS 986365; BMS986365; Gridegalutamide; |
| Molecular Formula | C41H45F3N8O5S |
| Molecular Weight | 818.91 |
| Smile | CC(C1=O)(C)N(C2=CC=C(OCCN3C[C@@H](C)N(CC(NC4=CC=CC(NC5C(NC(CC5)=O)=O)=C4)=O)CC3)C(CC)=C2)C(N1C6=CC(C(F)(F)F)=C(C#N)C=C6)=S |
| InChiKey | YUVGVJYLOFTILT-NHYGQJMQSA-N |
| InChi | InChI=1S/C41H45F3N8O5S/c1-5-26-19-31(52-39(58)51(38(56)40(52,3)4)30-10-9-27(22-45)32(21-30)41(42,43)44)11-13-34(26)57-18-17-49-15-16-50(25(2)23-49)24-36(54)47-29-8-6-7-28(20-29)46-33-12-14-35(53)48-37(33)55/h6-11,13,19-21,25,33,46H,5,12,14-18,23-24H2,1-4H3,(H,47,54)(H,48,53,55)/t25-,33?/m1/s1 |
| CAS Number | 2446928-30-7 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
