Giredestrant
Catalog No: 21248
CAS Number: 1953133-47-5
Purity: ≧98.0%
Giredestrant, also known as GDC-9545 and RG6171, is a SERD. GDC-9545 is an orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, SERD GDC-9545 specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that promotes ER degradation.
For research use only. We do not sell to patients.
Chemical Information
| Name | Giredestrant |
|---|---|
| Iupac Chemical Name | 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol |
| Synonyms | GDC-9545 ; GDC9545 ; GDC 9545 ; RG6171 ; RG-6171 ; RG 6171 ; Giredestrant ; |
| Molecular Formula | C27H31F5N4O |
| Molecular Weight | 522.564 |
| Smile | C[C@@H]1CC(C2=C(N3)C=CC=C2)=C3[C@@H](C4=C(C=C(C=C4F)NC5CN(C5)CCCF)F)N1CC(CO)(F)F |
| InChiKey | GQCXHIKRWBIQMD-AKJBCIBTSA-N |
| InChi | InChI=1S/C27H31F5N4O/c1-16-9-20-19-5-2-3-6-23(19)34-25(20)26(36(16)14-27(31,32)15-37)24-21(29)10-17(11-22(24)30)33-18-12-35(13-18)8-4-7-28/h2-3,5-6,10-11,16,18,26,33-34,37H,4,7-9,12-15H2,1H3/t16-,26-/m1/s1 |
| CAS Number | 1953133-47-5 |
| Related CAS | 1953133-47-5 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Yellow Solid |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
