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Ganetespib(STA-9090)

Catalog No.: 52021
Cas No.: 888216-25-9
Purity : 98% 
52021 - Ganetespib(STA-9090) | CAS 888216-25-9

Catalog number : 52021

CAS number : 888216-25-9

Molecular Formula : C20H20N4O3 

Molecular Weight : 364.4 

Iupac Chemical Name : 5-(2,4-dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-2H-1,2,4-triazol-3(4H)-one 

Smile : OC1=C(C=C(C(=C1)O)C(C)C)C=1N(C(NN1)=O)C=1C=C2C=CN(C2=CC1)C

InChiKey : RVAQIUULWULRNW-UHFFFAOYSA-N

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SynonymsGanetespib,STA-9090,STA9090,STA 9090 
Molecular FormulaC20H20N4O3 
Molecular Weight364.4 
Appearanceoff-white solid 
Purity98% 
Solubility5mg/ml in DMSO 
Storage3 years -20ºCpowder 6 months-80ºCin solvent 
Shipping ConditionShipped under ambient temperature 
SmileOC1=C(C=C(C(=C1)O)C(C)C)C=1N(C(NN1)=O)C=1C=C2C=CN(C2=CC1)C
InChiKeyRVAQIUULWULRNW-UHFFFAOYSA-N
InChiInChI=1S/C20H20N4O3/c1-11(2)14-9-15(18(26)10-17(14)25)19-21-22-20(27)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,25-26H,1-3H3,(H,22,27)
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Ganetespib blocked the ability of HSP90 to bind to biotinylated geldanamycin and disrupted the association of HSP90 with its cochaperone, p23, more potently than 17-AAG. In genomically defined NSCLC cell lines, ganetespib caused depletion of receptor tyrosine kinases, extinguishing of downstream signaling, inhibition of proliferation and induction of apoptosis with IC(50) values ranging 2 to 30 nmol/L, substantially lower than those required for 17-AAG (20-3,500 nmol/L). Ganetespib was also approximately 20-fold more potent in isogenic Ba/F3 pro-B cells rendered IL-3 independent by expression of EGFR and ERBB2 mutants. 

phase

IC50

target

Phase 3 Study

4 nM for OSA 8 cells

Non-Small-Cell Lung Adenocarcinoma













 


 

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