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GW 627368

Catalog No.: 91003
Cas No.: 439288-66-1
Purity : 98% 
91003 - GW 627368 | CAS 439288-66-1

Catalog number : 91003

CAS number : 439288-66-1

Molecular Formula : C30H28N2O6S 

Molecular Weight : 544.6 

Chemical Name : GW 627368

Smile : CCOc1c2ccccc2c(c3c1CN(C3=O)c4ccc(cc4)CC(=O)NS(=O)(=O)c5ccccc5)OCC

InChiKey : XREWXJVMYAXCJV-UHFFFAOYSA-N

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Synonyms4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)-benzeneacetamide 
Molecular FormulaC30H28N2O6S 
Molecular Weight544.6 
AppearanceCrystalline Solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileCCOc1c2ccccc2c(c3c1CN(C3=O)c4ccc(cc4)CC(=O)NS(=O)(=O)c5ccccc5)OCC
InChiKeyXREWXJVMYAXCJV-UHFFFAOYSA-N
InChiInChI=1S/C30H28N2O6S/c1-3-37-28-23-12-8-9-13-24(23)29(38-4-2)27-25(28)19-32(30(27)34)21-16-14-20(15-17-21)18-26(33)31-39(35,36)22-10-6-5-7-11-22/h5-17H,3-4,18-19H2,1-2H3,(H,31,33)
MDLMFCD12912327
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GW 627368X is a potent and selective competitive antagonist of the EP4 receptor with additional human TP receptor affinity. In competition radioligand bioassays, GW 627368X had affinity for human EP4 and TP receptors with Ki values of 100 nM and 158 nM, respectively. Affinity for all other human prostanoid receptors is >5.0 M. In human washed platelets, GW 627368X produced 100% inhibition of U-46619 (EC100)-induced aggregation at a concentration of 10 M. 

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