GSKJ1
Catalog No: 191255
CAS Number: 1373422-53-7
Purity: >98%
GSKJ1 is a selective and potent histone demethylase inhibitor (GSK-J1) that has significant activity (IC50 60 nM for human JmjD3) in vitro and in cells using an ester derivative (GSK-J4: 1 µM < IC50 < 10 µM; e.g. 9 µM in primary human macrophages).
For research use only. We do not sell to patients.
Chemical Information
| Name | GSKJ1 |
|---|---|
| Iupac Chemical Name | 3-((2-(pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoic acid |
| Synonyms | GSKJ1; GSKJ 1; GSKJ-1. |
| Molecular Formula | C22H23N5O2 |
| Molecular Weight | 389.459 |
| Smile | O=C(O)CCNC1=NC(C2=CC=CC=N2)=NC(N3CCC4=CC=CC=C4CC3)=C1 |
| InChiKey | AVZCPICCWKMZDT-UHFFFAOYSA-N |
| InChi | InChI=1S/C22H23N5O2/c28-21(29)8-12-24-19-15-20(26-22(25-19)18-7-3-4-11-23-18)27-13-9-16-5-1-2-6-17(16)10-14-27/h1-7,11,15H,8-10,12-14H2,(H,28,29)(H,24,25,26) |
| CAS Number | 1373422-53-7 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid to white solid |
|---|---|
| Purity | >98% |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
