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GSK343

Catalog No.: 122402
Cas No.: 1346704-33-3
Purity : 98% 
122402 - GSK343 | CAS 1346704-33-3

Catalog number : 122402

CAS number : 1346704-33-3

Molecular Formula : C31H39N7O2 

Molecular Weight : 541.687 

Iupac Chemical Name : N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-propan-2-ylindazole-4-carboxamide 

Smile : CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C

InChiKey : ULNXAWLQFZMIHX-UHFFFAOYSA-N

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SynonymsGSK-343; GSK 343 
Molecular FormulaC31H39N7O2 
Molecular Weight541.687 
AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileCCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C
InChiKeyULNXAWLQFZMIHX-UHFFFAOYSA-N
InChiInChI=1S/C31H39N7O2/c1-6-7-23-14-21(4)35-31(40)26(23)18-33-30(39)25-15-24(16-28-27(25)19-34-38(28)20(2)3)22-8-9-32-29(17-22)37-12-10-36(5)11-13-37/h8-9,14-17,19-20H,6-7,10-13,18H2,1-5H3,(H,33,39)(H,35,40)
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GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM, showing 60 fold selectivity against EZH1, and >1000 fold selectivity against other histone methyltransferases. 

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