GSK321
Catalog No: 2017821
CAS Number: 1816331-63-1
Purity: 98.0%
GSK321 is a potent and selective IDH1 mutant inhibitor. GSK321 potently inhibited intracellular 2-HG production in HT-1080 cells, with a half-maximal effective concentration (EC50) of 85 nM by LC/MS/MS analysis.
For research use only. We do not sell to patients.
Chemical Information
| Name | GSK321 |
|---|---|
| Iupac Chemical Name | (R)-1-(4-Fluorobenzyl)-N-(3-((S)-1-hydroxyethyl)phenyl)-7-methyl-5-(1H-pyrrole-2-carbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide |
| Synonyms | GSK321|GSK 321|GSK-321 |
| Molecular Formula | C28H28FN5O3 |
| Molecular Weight | 501.5624 |
| Smile | FC1=CC=C(CN2N=C(C=3CN(C[C@H](C32)C)C(=O)C=3NC=CC3)C(=O)NC3=CC(=CC=C3)[C@H](C)O)C=C1 |
| InChiKey | IVFDDVKCCBDPQZ-MSOLQXFVSA-N |
| InChi | InChI=1S/C28H28FN5O3/c1-17-14-33(28(37)24-7-4-12-30-24)16-23-25(27(36)31-22-6-3-5-20(13-22)18(2)35)32-34(26(17)23)15-19-8-10-21(29)11-9-19/h3-13,17-18,30,35H,14-16H2,1-2H3,(H,31,36)/t17-,18+/m1/s1 |
| CAS Number | 1816331-63-1 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | off-white solid |
|---|---|
| Purity | 98.0% |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
