GSK2636771
Catalog No: 52618
CAS Number: 1372540-25-4
Purity: 98% by HPLC
GSK2636771 is a potent, orally bioavailable and selective inhibitor of PI3K (0.89 nM), with >900-fold selectivity over PI3K/PI3K and >10-fold over PI3K. It inhibits AKT phosphorylation and downstream signalling measured as decrease of PRAS40-, GSK3-, and RPS6-phosphorylation in PTEN mutant cell lines.
For research use only. We do not sell to patients.
Chemical Information
| Name | GSK2636771 |
|---|---|
| Iupac Chemical Name | 2-methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-6-morpholino-1H-benzo[d]imidazole-4-carboxylic acid |
| Synonyms | GSK-2636771,GSK 2636771 |
| Molecular Formula | C22H22F3N3O3 |
| Molecular Weight | 433.42 |
| Smile | CC1=NC2=C(N1CC1=C(C(=CC=C1)C(F)(F)F)C)C=C(C=C2C(=O)O)N2CCOCC2 |
| InChiKey | XTKLTGBKIDQGQL-UHFFFAOYSA-N |
| InChi | InChI=1S/C22H22F3N3O3/c1-13-15(4-3-5-18(13)22(23,24)25)12-28-14(2)26-20-17(21(29)30)10-16(11-19(20)28)27-6-8-31-9-7-27/h3-5,10-11H,6-9,12H2,1-2H3,(H,29,30) |
| CAS Number | 1372540-25-4 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | solid |
|---|---|
| Purity | 98% by HPLC |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
