GSK-2269557 (free base) is a potent and selective PI3Kδ inhibitor over the closely related isoforms.
GSK-2269557 are active in a disease relevant brown Norway rat acute OVA model of Th2-driven lung inflammation. PI3Kδ is highly enriched
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| Name | GSK2269557 free base |
|---|---|
| Iupac Chemical Name | 6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole |
| Synonyms | GSK 2269557 free base; GSK-2269557 free base |
| Molecular Formula | C26H28N6O |
| Molecular Weight | 440.54 |
| Smile | N1C=CC2=C(C=CC=C12)C1=CC(=C2C=NNC2=C1)C=1OC(=CN1)CN1CCN(CC1)C(C)C |
| InChiKey | MCIDWGZGWVSZMK-UHFFFAOYSA-N |
| InChi | InChI=1S/C26H28N6O/c1-17(2)32-10-8-31(9-11-32)16-19-14-28-26(33-19)22-12-18(13-25-23(22)15-29-30-25)20-4-3-5-24-21(20)6-7-27-24/h3-7,12-15,17,27H,8-11,16H2,1-2H3,(H,29,30) |
| CAS Number | 1254036-71-9 |
| Related CAS |
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20℃powder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
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