GSK0660
Catalog No: 16123009
CAS Number: 1014691-61-2
Purity: 98%
GSK0660 is a selective PPAR antagonist. GSK0660 differentially regulated 273 transcripts in TNF-treated cells compared to TNF alone. A pathway analysis revealed the enrichment of cytokine-cytokine receptor signaling. In particular, GSK0660 blocks the TNF-induced upregulation of CCL8, a chemokine involved in leukocyte recruitment. GSK0660 blocks the effect of TNF on the expressions of cytokines involved in leukocyte recruitment, including CCL8, CCL17, and CXCL10 and it may therefore block TNF-induced retinal leukostasis.
For research use only. We do not sell to patients.
Chemical Information
| Name | GSK0660 |
|---|---|
| Iupac Chemical Name | GSK0660 |
| Synonyms | GSK-0660; GSK 0660 |
| Molecular Formula | C19H18N2O5S2 |
| Molecular Weight | 418.48 |
| Smile | COc1cc(ccc1NS(=O)(=O)c2ccsc2C(=O)OC)Nc3ccccc3 |
| InChiKey | NDFKBGWLUHKMFY-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H18N2O5S2/c1-25-16-12-14(20-13-6-4-3-5-7-13)8-9-15(16)21-28(23,24)17-10-11-27-18(17)19(22)26-2/h3-12,20-21H,1-2H3 |
| CAS Number | 1014691-61-2 |
| MDL | MFCD12828770 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
