GNF-PF-3777
GNF-PF-3777 is a derivative of tryptanthrin.
For research use only. We do not sell to patients.
Chemical Information
| Name | GNF-PF-3777 |
|---|---|
| Iupac Chemical Name | 8-nitro-indolo[2,1-b]quinazoline-6,12-dione |
| Synonyms | 8-Nitrotryptanthrin, GNF-PF-3777 |
| Molecular Formula | C15H7N3O4 |
| Molecular Weight | 293.24 |
| Smile | O=C1C2=CC=CC=C2N=C3N1C(C=CC([N+]([O-])=O)=C4)=C4C3=O |
| InChiKey | UFMQJYHLIUACCG-UHFFFAOYSA-N |
| InChi | InChI=1S/C15H7N3O4/c19-13-10-7-8(18(21)22)5-6-12(10)17-14(13)16-11-4-2-1-3-9(11)15(17)20/h1-7H |
| CAS Number | 77603-42-0 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1. Yang, S., Li, X., Hu, F., et al. Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice. J. Med. Chem. 56(21), 8321-8331 (2013).
2. Sharma, V.M., Prasanna, P., Seshu, K.V., et al. Novel indolo[2,1-b]quinazoline analogues as cytostatic agents: Synthesis, biological evaluation and structure-activity relationship. Bioorg. Med. Chem. Lett. 12(17), 2303-2307 (2002).
3. Hwang, J.-M., Oh, T., Kaneko, T., et al. Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents. J. Nat. Prod. 76(3), 354-367 (2013).
4. Kawakami, J., Matsushima, N., Ogawa, O., et al. Antibacterial and antifungal activities of tryptanthrin derivatives. Trans. Mater. Res. Soc. Jpn. 36(4), 603-606 (2011).
5. Scovill, J., Blank, E., Konnick, M., et al. Antitrypanosomal activities of tryptanthrins. Antimicrob. Agents Chemother. 46(3), 882-883 (2002).
Chemical Structure
