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Catalog No.: 16062801
Cas No.: 1453848-26-4
Purity : 98% by HPLC 
16062801 - GDC-0994 | CAS 1453848-26-4

Catalog number : 16062801

CAS number : 1453848-26-4

Molecular Formula : C21H18ClFN6O2 

Molecular Weight : 440.86 

Iupac Chemical Name : (S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one 

Smile : ClC1=C(C=C(C=C1)[C@@H](CO)N1C(C=C(C=C1)C1=NC(=NC=C1)NC1=CC=NN1C)=O)F


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SynonymsGDC0994; GDC-0994 
Molecular FormulaC21H18ClFN6O2 
Molecular Weight440.86 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
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GDC-0994, also known as RG7842, is an orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. This prevents ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. Check for active clinical trials or closed clinical trials using this agent 

1453848-26-4 - Request Bulk Quote

1453848-26-4 - Request Bulk Quote