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GDC-0623

Catalog No.: 010811
Cas No.: 1168091-68-6
Purity : 98% 
010811 - GDC-0623 | CAS 1168091-68-6

Catalog number : 010811

CAS number : 1168091-68-6

Molecular Formula : C16H14FIN4O3 

Molecular Weight : 456.21 

Iupac Chemical Name : 5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide 

Smile : C1=CC(=C(C=C1I)F)NC2=C(C=CC3=CN=CN32)C(=O)NOCCO

InChiKey : RFWVETIZUQEJEF-UHFFFAOYSA-N

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SynonymsGDC0623; GDC 0623 
Molecular FormulaC16H14FIN4O3 
Molecular Weight456.21 
AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileC1=CC(=C(C=C1I)F)NC2=C(C=CC3=CN=CN32)C(=O)NOCCO
InChiKeyRFWVETIZUQEJEF-UHFFFAOYSA-N
InChiInChI=1S/C16H14FIN4O3/c17-13-7-10(18)1-4-14(13)20-15-12(16(24)21-25-6-5-23)3-2-11-8-19-9-22(11)15/h1-4,7-9,20,23H,5-6H2,(H,21,24)
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GDC-0623 is a potent, ATP-uncompetitive inhibitors of MEK1(Ki=0.13 nM, +ATP); 6-fold weaker potency against HCT116 (KRAS(G13D), EC50=42 nM) versus A375 (BRAF(V600E), EC50=7 nM). 

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