GDC-046
Catalog No: L20342
CAS Number: 1258292-64-6
Purity: 98% Min.
GDC-046 is a potent, selective, and orally bioavailable TYK2 inhibitor for TYK2, JAK1, JAK2, and JAK3, respectively.
For research use only. We do not sell to patients.
Chemical Information
| Name | GDC-046 |
|---|---|
| Iupac Chemical Name | 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide |
| Synonyms | GDC-046; GDC 046; GDC046 |
| Molecular Formula | C16H13Cl2N3O2 |
| Molecular Weight | 350.20 |
| Smile | O=C(NC1=CC(NC(C2CC2)=O)=NC=C1)C3=C(Cl)C=CC=C3Cl |
| InChiKey | IAFNAEGXTKTGHN-UHFFFAOYSA-N |
| InChi | InChI=1S/C16H13Cl2N3O2/c17-11-2-1-3-12(18)14(11)16(23)20-10-6-7-19-13(8-10)21-15(22)9-4-5-9/h1-3,6-9H,4-5H2,(H2,19,20,21,22,23) |
| CAS Number | 1258292-64-6 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Liang J, van Abbema A, Balazs M, et al. Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors. J Med Chem. 2013;56(11):4521-4536. doi:10.1021/jm400266t
Chemical Structure
