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GDC-0152

Catalog No.: 16071101
Cas No.: 873652-48-3
Purity : 98% by HPLC 
16071101 - GDC-0152 | CAS 873652-48-3

Catalog number : 16071101

CAS number : 873652-48-3

Molecular Formula : C25H34N6O3S 

Molecular Weight : 498.64 

Iupac Chemical Name : (S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(4-phenyl-1,2,3-thiadiazol-5-yl)pyrrolidine-2-carboxamide 

Smile : C1(CCCCC1)[C@@H](C(=O)N1[C@@H](CCC1)C(=O)NC1=C(N=NS1)C1=CC=CC=C1)NC([C@H](C)NC)=O

InChiKey : WZRFLSDVFPIXOV-LRQRDZAKSA-N

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SynonymsGDC0152; GDC 0152 
Molecular FormulaC25H34N6O3S 
Molecular Weight498.64 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileC1(CCCCC1)[C@@H](C(=O)N1[C@@H](CCC1)C(=O)NC1=C(N=NS1)C1=CC=CC=C1)NC([C@H](C)NC)=O
InChiKeyWZRFLSDVFPIXOV-LRQRDZAKSA-N
InChiInChI=1S/C25H34N6O3S/c1-16(26-2)22(32)27-21(18-12-7-4-8-13-18)25(34)31-15-9-14-19(31)23(33)28-24-20(29-30-35-24)17-10-5-3-6-11-17/h3,5-6,10-11,16,18-19,21,26H,4,7-9,12-15H2,1-2H3,(H,27,32)(H,28,33)/t16-,19-,21-/m0/s1
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GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0152 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2, which may inhibit their activities and promote the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. 

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