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GCN2iB

Catalog No.: 2071802
Cas No.: 2183470-12-2
Purity : 98%

GCN2iB is an ATP-competitive GCN2 inhibitory compound with a better pharmacokinetic profile. GCN2iB showed an IC50 value of 2.4 nmol/L for GCN2 and potent cellular activity. 

For research use only. We do not sell to patients.

Chemical Information

NameGCN2iB
Iupac Chemical NameN-[3-[2-(2-Amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxy- 3-pyridinesulfonamide
SynonymsGCN2iB
Molecular FormulaC₁₈H₁₂ClF₂N₅O₃S
Molecular Weight451.83
SmileO=S(C1=CC(Cl)=CN=C1OC)(NC2=CC=C(F)C(C#CC3=CN=C(N)N=C3)=C2F)=O
InChiKeyJGHVXJKGYJYWOP-UHFFFAOYSA-N
InChiInChI=1S/C18H12ClF2N5O3S/c1-29-17-15(6-11(19)9-23-17)30(27,28)26-14-5-4-13(20)12(16(14)21)3-2-10-7-24-18(22)25-8-10/h4-9,26H,1H3,(H2,22,24,25)
CAS Number2183470-12-2
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
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Formulationlight-yellow solid to off-white solid 
Purity98%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
HandlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
TargetsGCN2 inhibitor
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

2071802 - GCN2iB | CAS 2183470-12-2

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