G-1
G-1 is a selective agonist for GPER. It acts by blocking tubulin polymerization.
For research use only. We do not sell to patients.
Chemical Information
| Name | G-1 |
|---|---|
| Iupac Chemical Name | Syn-1-[4-(6-bromobenzo[1,3] dioxol-5yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone |
| Synonyms | G-1; G 1; G1; |
| Molecular Formula | C21H18BrNO3 |
| Molecular Weight | 412.28 |
| Smile | CC(C1=CC2=C(NC(C3=C(Br)C=C(OCO4)C4=C3)C5C2C=CC5)C=C1)=O |
| InChiKey | VHSVKVWHYFBIFJ-UHFFFAOYSA-N |
| InChi | InChI=1S/C21H18BrNO3/c1-11(24)12-5-6-18-15(7-12)13-3-2-4-14(13)21(23-18)16-8-19-20(9-17(16)22)26-10-25-19/h2-3,5-9,13-14,21,23H,4,10H2,1H3 |
| CAS Number | 881639-98-1 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Thomas P. Rapid steroid hormone actions initiated at the cell surface and the receptors that mediate them with an emphasis on recent progress in fish models. Gen Comp Endocrinol. 2012 Feb 1;175(3):367-83. doi: 10.1016/j.ygcen.2011.11.032. Epub 2011 Nov 29. Review. PubMed PMID: 22154643; PubMed Central PMCID: PMC3264783.
2: Revankar CM, Mitchell HD, Field AS, Burai R, Corona C, Ramesh C, Sklar LA, Arterburn JB, Prossnitz ER. Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30. ACS Chem Biol. 2007 Aug 17;2(8):536-44. Epub 2007 Jul 27. PubMed PMID: 17655271.
3: Song RX, Fan P, Yue W, Chen Y, Santen RJ. Role of receptor complexes in the extranuclear actions of estrogen receptor alpha in breast cancer. Endocr Relat Cancer. 2006 Dec;13 Suppl 1:S3-13. Review. PubMed PMID: 17259556.
4: Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science. 2005 Mar 11;307(5715):1625-30. Epub 2005 Feb 10. PubMed PMID: 15705806.
Chemical Structure
