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Foretinib(GSK1363089)

Catalog No.: 51705
Cas No.: 849217-64-7
Purity : 98% 

Foretinib (GSK1363089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50of 0.4 nM and 0.9 nM. Less potent against Ron, Flt-1/3/4, Kit, PDGFR/ and Tie-2, and little activity to FGFR1 and EGFR. Phase 2. 

For research use only. We do not sell to patients.

Chemical Information

NameForetinib(GSK1363089)
Iupac Chemical NameN-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
SynonymsForetinib,GSK1363089,XL880 
Molecular FormulaC34H34F2N4O6 
Molecular Weight632.65 
SmileFC=1C=C(C=CC1OC1=CC=NC2=CC(=C(C=C12)OC)OCCCN1CCOCC1)N(C(=O)C1(CC1)C(=O)N)C1=CC=C(C=C1)F
InChiKeyFCGJXAOTZFGHNQ-UHFFFAOYSA-N
InChiInChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-39-14-17-44-18-15-39)38-12-9-28(25)46-29-8-7-24(19-26(29)36)40(23-5-3-22(35)4-6-23)33(42)34(10-11-34)32(37)41/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H2,37,41)
CAS Number849217-64-7
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationoff-white solid 
Purity98% 
Storage3 years -20ºCpowder 
Solubility5mg/ml in DMSO 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

51705 - Foretinib(GSK1363089) | CAS 849217-64-7

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