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Catalog No.: 16071102
Cas No.: 885060-09-3
Purity : 98% by HPLC 
16071102 - Filanesib | CAS 885060-09-3

Catalog number : 16071102

CAS number : 885060-09-3

Molecular Formula : C20H22F2N4O2S 

Molecular Weight : 420.48 

Iupac Chemical Name : (S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide. 

Smile : CN(C(=O)N1[C@](SC(=N1)c2cc(ccc2F)F)(CCCN)c3ccccc3)OC.C(=O)(C(F)(F)F)O


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SynonymsARRY-520; ARRY 520 
Molecular FormulaC20H22F2N4O2S 
Molecular Weight420.48 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
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Filanesib, also known as ARRY-520, is a synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent does not cause the peripheral neuropathy that is often associated with tubulin-targeting agents. KSP is an ATP-dependent microtubule motor protein that is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis. 

885060-09-3 - Request Bulk Quote

885060-09-3 - Request Bulk Quote