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Fezolinetant

Catalog No.: 18722
Cas No.: 1629229-37-3
Purity : >98%

Fezolinetant, also known as ESN-364, is Neurokinin-3 (NK-3) receptor antagonist which has been optimized for use in women’s health, and is being developed for sex-hormone related disorders such as endometriosis, polycystic ovarian syndrome and uterine fibroids.

For research use only. We do not sell to patients.

Chemical Information

NameFezolinetant
Iupac Chemical Name(R)-(4-fluorophenyl)(8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone
SynonymsFezolinetant ; ESN-364 ; ESN 364 ; ESN364
Molecular FormulaC16H15FN6OS
Molecular Weight358.3954
SmileO=C(C1=CC=C(F)C=C1)N2[C@H](C)C3=NN=C(C4=NC(C)=NS4)N3CC2
InChiKeyPPSNFPASKFYPMN-SECBINFHSA-N
InChiInChI=1S/C16H15FN6OS/c1-9-13-19-20-14(15-18-10(2)21-25-15)23(13)8-7-22(9)16(24)11-3-5-12(17)6-4-11/h3-6,9H,7-8H2,1-2H3/t9-/m1/s1
CAS Number1629229-37-3
Related CAS1629229-37-3

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
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FormulationOff-white solid to white solid
Purity>98%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature
HS Code
Coming soon.
TargetsNeurokinin-3 (NK-3) receptor antagonist
Mechanism
Cell study
Animal study
Clinical study

1: Fraser GL, Ramael S, Hoveyda HR, Gheyle L, Combalbert J. The NK3 Receptor Antagonist ESN364 Suppresses Sex Hormones in Men and Women. J Clin Endocrinol Metab. 2016 Feb;101(2):417-26. doi: 10.1210/jc.2015-3621. Epub 2015 Dec 14. PubMed PMID: 26653113.

2: Fraser GL, Hoveyda HR, Clarke IJ, Ramaswamy S, Plant TM, Rose C, Millar RP. The NK3 Receptor Antagonist ESN364 Interrupts Pulsatile LH Secretion and Moderates Levels of Ovarian Hormones Throughout the Menstrual Cycle. Endocrinology. 2015 Nov;156(11):4214-25. doi: 10.1210/en.2015-1409. Epub 2015 Aug 25. PubMed PMID: 26305889.


Chemical Structure

18722 - Fezolinetant | CAS 1629229-37-3

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