Fevipiprant ( NVP-QAW039 )
Fevipiprant (QAW039; NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 1.1nM at the CRTh2 receptor and an IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood.
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Chemical Information
| Name | Fevipiprant ( NVP-QAW039 ) |
|---|---|
| Iupac Chemical Name | 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid |
| Synonyms | Fevipiprant ; NVP-QAW039 ; NVPQAW039 ; NVP QAW039 ; |
| Molecular Formula | C19H17F3N2O4S |
| Molecular Weight | 426.4 |
| Smile | CC1=C(C=2C(=NC=CC2)N1CC1=C(C=C(C=C1)S(=O)(=O)C)C(F)(F)F)CC(=O)O |
| InChiKey | GFPPXZDRVCSVNR-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H17F3N2O4S/c1-11-15(9-17(25)26)14-4-3-7-23-18(14)24(11)10-12-5-6-13(29(2,27)28)8-16(12)19(20,21)22/h3-8H,9-10H2,1-2H3,(H,25,26) |
| CAS Number | 872365-14-5 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | off-white powder |
|---|---|
| Purity | ≧98.0% |
| Storage | 3 years -20℃powder 6 months-80℃in solvent |
| Solubility | Soluble in DMSO, not in water |
| Handling | |
| Shipping Condition | Shipped under ambient temperature. |
| HS Code |
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| Mechanism | |
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| Clinical study |
1. Hardman C, Chen W etc. Fevipiprant, a selective prostaglandin D2 receptor 2 antagonist, inhibits human group 2 innate lymphoid cell aggregation and function. J Allergy Clin Immunol. 2019 Feb 28. pii: S0091-6749(19)30278-7. doi: 10.1016/j.jaci.2019.02.015. [Epub ahead of print]
2. Murillo JC, Dimov V, Gonzalez-Estrada A. An evaluation of fevipiprant for the treatment of asthma: a promising new therapy? Expert Opin Pharmacother. 2018 Dec;19(18):2087-2093. doi: 10.1080/14656566.2018.1540589. Epub 2018 Nov 3.
Chemical Structure
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