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FTI-2148

Catalog No.: 111897
Cas No.: 251577-09-0
Purity : 98% Min.
111897 - FTI-2148 | CAS 251577-09-0

Catalog number : 111897

CAS number : 251577-09-0

Molecular Formula : C24H28N4O3S

Molecular Weight : 452.57

Iupac Chemical Name : L-Methionine, N-[[5-[[(1H-imidazol-4-ylmethyl)amino]methyl]-2'-methyl[1,1'-biphenyl]-2-yl]carbonyl]-

Smile : N1C=NC(=C1)CNCC=1C=CC(=C(C1)C1=C(C=CC=C1)C)C(=O)N[C@@H](CCSC)C(=O)O

InChiKey : KULAYTGUTXCHSV-QFIPXVFZSA-N

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SynonymsFTI2148; FTI 2148; FTI-2148.
Molecular FormulaC24H28N4O3S
Molecular Weight452.57
Appearancecrystalline solid 
Purity98% Min.
SolubilitySoluble in DMSO, not in water
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature 
SmileN1C=NC(=C1)CNCC=1C=CC(=C(C1)C1=C(C=CC=C1)C)C(=O)N[C@@H](CCSC)C(=O)O
InChiKeyKULAYTGUTXCHSV-QFIPXVFZSA-N
InChiInChI=1S/C24H28N4O3S/c1-16-5-3-4-6-19(16)21-11-17(12-25-13-18-14-26-15-27-18)7-8-20(21)23(29)28-22(24(30)31)9-10-32-2/h3-8,11,14-15,22,25H,9-10,12-13H2,1-2H3,(H,26,27)(H,28,29)(H,30,31)/t22-/m0/s1
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FTI-2148 is a potent farnesyltransferase inhibitor with potential antitumor activity.

1: Guida WC, Hamilton AD, Crotty JW, Sebti SM. Protein farnesyltransferase: flexible docking studies on inhibitors using computational modeling. J Comput Aided Mol Des. 2005 Dec;19(12):871-85. Epub 2006 May 12. PubMed PMID: 16607571.

2: Carrico D, Ohkanda J, Kendrick H, Yokoyama K, Blaskovich MA, Bucher CJ, Buckner FS, Van Voorhis WC, Chakrabarti D, Croft SL, Gelb MH, Sebti SM, Hamilton AD. In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability. Bioorg Med Chem. 2004 Dec 15;12(24):6517-26. PubMed PMID: 15556768.

3: Sun J, Ohkanda J, Coppola D, Yin H, Kothare M, Busciglio B, Hamilton AD, Sebti SM. Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice. Cancer Res. 2003 Dec 15;63(24):8922-9. PubMed PMID: 14695209.

4: Sun J, Blaskovich MA, Knowles D, Qian Y, Ohkanda J, Bailey RD, Hamilton AD, Sebti SM. Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine. Cancer Res. 1999 Oct 1;59(19):4919-26. PubMed PMID: 10519405.


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