FRAX597
Catalog No: 72803
CAS Number: 1286739-19-2
Purity: 97%
FRAX597 inhibits the proliferation of NF2-deficient schwannoma cells in culture and displayed potent anti-tumor activity in vivo, impairing schwannoma development in an orthotopic model of NF2. These studies identify a novel class of orally available ATP-competitive Group I PAK inhibitors with significant potential for the treatment of NF2 and other cancers.
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Chemical Information
| Name | FRAX597 |
|---|---|
| Iupac Chemical Name | 6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one |
| Synonyms | FRAX 597; FRAX-597 |
| Molecular Formula | C29H28ClN7OS |
| Molecular Weight | 558.10 |
| Smile | ClC1=C(C=CC(=C1)C1=CN=CS1)C1=CC2=C(N=C(N=C2)NC2=CC=C(C=C2)N2CCN(CC2)C)N(C1=O)CC |
| InChiKey | DHUJCQOUWQMVCG-UHFFFAOYSA-N |
| InChi | InChI=1S/C29H28ClN7OS/c1-3-37-27-20(14-24(28(37)38)23-9-4-19(15-25(23)30)26-17-31-18-39-26)16-32-29(34-27)33-21-5-7-22(8-6-21)36-12-10-35(2)11-13-36/h4-9,14-18H,3,10-13H2,1-2H3,(H,32,33,34) |
| CAS Number | 1286739-19-2 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 97% |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
