Welcome to Sun-shine chemical
+86-17702719238 sales@sun-shinechem.com

FIIN-3

Catalog No: 16122945
CAS Number: 1637735-84-2
Purity: 98% 

FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-3 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. FIIN-3 has the unprecedented ability to inhibit both the EGF receptor (EGFR) and FGFR covalently by targeting two distinct cysteine residues. FIIN-3 bound with FGFR4 V550L and EGFR L858R. (Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77.) 

For research use only. We do not sell to patients.

Chemical Information

NameFIIN-3
Iupac Chemical NameFIIN-3 
SynonymsFIIN3; FIIN 3 
Molecular FormulaC34H36Cl2N8O4 
Molecular Weight691.60684 
InChiKey
InChi
CAS Number1637735-84-2
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
Request Bulk Quote Download MSDS Tel : +86-177 0271 9238   Email : sales@sun-shinechem.com
Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16122945 - FIIN-3 | CAS 1637735-84-2

Quick Order

Change