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FIIN-2

Catalog No.: 16062117
Cas No.: 1633044-56-0
Purity : 98% by HPLC 
16062117 - FIIN-2 | CAS 1633044-56-0

Catalog number : 16062117

CAS number : 1633044-56-0

Molecular Formula : C35H38N8O4 

Molecular Weight : 634.72742 

Iupac Chemical Name : N-(4-((3-(3,5-dimethoxyphenyl)-7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide 

Smile : COC=1C=C(C=C(C1)OC)N1C(N(C2=NC(=NC=C2C1)NC1=CC=C(C=C1)N1CCN(CC1)C)CC1=CC=C(C=C1)NC(C=C)=O)=O

InChiKey : DVBPRWJMHURKHP-UHFFFAOYSA-N

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SynonymsFIIN 2; FIIN-2 
Molecular FormulaC35H38N8O4 
Molecular Weight634.72742 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileCOC=1C=C(C=C(C1)OC)N1C(N(C2=NC(=NC=C2C1)NC1=CC=C(C=C1)N1CCN(CC1)C)CC1=CC=C(C=C1)NC(C=C)=O)=O
InChiKeyDVBPRWJMHURKHP-UHFFFAOYSA-N
InChiInChI=1S/C35H38N8O4/c1-5-32(44)37-26-8-6-24(7-9-26)22-43-33-25(23-42(35(43)45)29-18-30(46-3)20-31(19-29)47-4)21-36-34(39-33)38-27-10-12-28(13-11-27)41-16-14-40(2)15-17-41/h5-13,18-21H,1,14-17,22-23H2,2-4H3,(H,37,44)(H,36,38,39)
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FIIN-2 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-2 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. FIIN-2 also binds in the DFG-out mode despite lacking a functional group necessary to occupy the pocket vacated upon the DFG-out flip.  

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