FHD-286
Catalog No: 20471
CAS Number: 2671128-05-3
Purity: ≧98.0%
FHD-286 is an oral, small-molecule, selective, allosteric inhibitor of BRG1 and BRM in early clinical development at Foghorn Therapeutics for the treatment of relapsed and/or refractory acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).
For research use only. We do not sell to patients.
Chemical Information
| Name | FHD-286 |
|---|---|
| Iupac Chemical Name | 1H-Pyrrole-3-carboxamide, N-[(1S)-2-[[4-[6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-pyridinyl]-2-thiazolyl]amino]-1-(methoxymethyl)-2-oxoethyl]-1-(methylsulfonyl)- |
| Synonyms | FHD-286; FHD 286; FHD286; |
| Molecular Formula | C24H30N6O6S2 |
| Molecular Weight | 562.66 |
| Smile | O=C(C1=CN(S(=O)(C)=O)C=C1)N[C@@H](COC)C(NC2=NC(C3=NC(N4C[C@@H](C)O[C@@H](C)C4)=CC=C3)=CS2)=O |
| InChiKey | JBLQNFBXKOAIHG-FCEWJHQRSA-N |
| InChi | InChI=1S/C24H30N6O6S2/c1-15-10-29(11-16(2)36-15)21-7-5-6-18(25-21)20-14-37-24(27-20)28-23(32)19(13-35-3)26-22(31)17-8-9-30(12-17)38(4,33)34/h5-9,12,14-16,19H,10-11,13H2,1-4H3,(H,26,31)(H,27,28,32)/t15-,16+,19-/m0/s1 |
| CAS Number | 2671128-05-3 |
| Related CAS | 2671128-05-3 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | BRG1 and BRM inhibitor |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
