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Entrectinib(RXDX-101)

Catalog No: 100504
CAS Number: 1108743-60-7
Purity: 98% by HPLC 

Entrectinib (RXDX-101) is a selective inhibitor for all three TRK receptor tyrosine kinases encoded by the three NTRK genes, as well as the ROS1 and ALK receptor tyrosine kinases.

For research use only. We do not sell to patients.

Chemical Information

NameEntrectinib(RXDX-101)
Iupac Chemical NameN-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide 
SynonymsRXDX-101;RXDX 101;RXDX101;Entrectinib;NMS-E628
Molecular FormulaC31H34F2N6O2 
Molecular Weight560.64 
SmileO=C(NC1=NNC2=C1C=C(CC3=CC(F)=CC(F)=C3)C=C2)C4=CC=C(N5CCN(C)CC5)C=C4NC6CCOCC6
InChiKeyHAYYBYPASCDWEQ-UHFFFAOYSA-N
InChiInChI=1S/C31H34F2N6O2/c1-38-8-10-39(11-9-38)25-3-4-26(29(19-25)34-24-6-12-41-13-7-24)31(40)35-30-27-17-20(2-5-28(27)36-37-30)14-21-15-22(32)18-23(33)16-21/h2-5,15-19,24,34H,6-14H2,1H3,(H2,35,36,37,40)
CAS Number1108743-60-7
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Ordering Information

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Formulationoff-white solid 
Purity98% by HPLC 
Storage3 years -20ºCpowder 6 months-80ºCin solvent 
SolubilitySoluble in DMSO to 20 mM 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

100504 - Entrectinib(RXDX-101) | CAS 1108743-60-7

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