Enarodustat ( JTZ-951 )
Catalog No: 2073104
CAS Number: 1262132-81-9
Purity: 98% Min.
Enarodustat ( JTZ-951 ) is an orally-active HIF-PH inhibitor with an EC50 of 0.22 Μm, that promotes erythropoiesis by accelerating the endogenous production of erythropoietin (EPO) and controlling the expression of molecules responsible for iron metabolism. The Phase 3 clinical studies confirmed efficacy in anemic patients with non-dialysis dependent CKD and dialysis dependent CKD. Furthermore, the favorable tolerability profile on safety of enarodustat was obtained during the studies
For research use only. We do not sell to patients.
Chemical Information
| Name | Enarodustat ( JTZ-951 ) |
|---|---|
| Iupac Chemical Name | N-[7-hydroxy-5-(2-phenylethyl)[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl]glycine |
| Synonyms | Enarodustat ; JTZ-951 ; JTZ 951 ; JTZ951 ; |
| Molecular Formula | C17H16N4O4 |
| Molecular Weight | 340.33 |
| Smile | O=C(O)CNC(C1=C(O)C=C(CCC2=CC=CC=C2)N3C1=NC=N3)=O |
| InChiKey | NALAUGMPMIVAOW-UHFFFAOYSA-N |
| InChi | InChI=1S/C17H16N4O4/c22-13-8-12(7-6-11-4-2-1-3-5-11)21-16(19-10-20-21)15(13)17(25)18-9-14(23)24/h1-5,8,10,22H,6-7,9H2,(H,18,25)(H,23,24) |
| CAS Number | 1262132-81-9 |
| Related CAS | 1262132-81-9 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Handling | Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code | 2933599090 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
_1262132-81-9.png)