Elacestrant dihydrochloride
Elacestrant dihydrochloride, also known as RAD1901, is an orally available, selective estrogen receptor degrader (SERD) and selective estrogen receptor modulator (SERM), with potential antineoplastic and estrogen-like activities. Upon oral administration of higher doses of RAD1901, this agent acts as a SERD, which binds to the estrogen receptor (ER) and induces a conformational change that results in the degradation of the receptor. This may inhibit the growth and survival of ER-expressing cancer cells. At lower doses of this agent, RAD1901 acts as a SERM and has estrogen-like effects in certain tissues, which can both reduce hot flashes and protect against bone loss. In addition, RAD1901 is able to cross the blood-brain barrier (BBB).
For research use only. We do not sell to patients.
Chemical Information
| Name | Elacestrant dihydrochloride |
|---|---|
| Iupac Chemical Name | (R)-6-(2-(ethyl(4-(2-(ethylamino)ethyl)benzyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol dihydrochloride |
| Synonyms | RAD1901 ; RAD-1901 ; RAD 1901 ; RAD1901 HCl ; Elacestrant dihydrochloride |
| Molecular Formula | C30H40Cl2N2O2 |
| Molecular Weight | 531.56 |
| Smile | Cl.Cl.C(C)N(C1=C(C=CC(=C1)OC)[C@H]1CC=2C=CC(=CC2CC1)O)CC1=CC=C(C=C1)CCNCC |
| InChiKey | XGFHYCAZOCBCRQ-FBHGDYMESA-N |
| InChi | InChI=1S/C30H38N2O2.2ClH/c1-4-31-17-16-22-6-8-23(9-7-22)21-32(5-2)30-20-28(34-3)14-15-29(30)26-11-10-25-19-27(33)13-12-24(25)18-26;;/h6-9,12-15,19-20,26,31,33H,4-5,10-11,16-18,21H2,1-3H3;2*1H/t26-;;/m1../s1 |
| CAS Number | 1349723-93-8 |
| Related CAS | 722533-56-4 (free base) |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white Solid |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Chemical Structure
