EX-527 S-enantiomer
Catalog No: 17011802
CAS Number: 848193-68-0
Purity: 98%
EX-527 S-enantiomer is a potent and selective SIRT1 inhibitor with IC50 of 123 nM; no inhibition on SIRT3. EX-527 S-enantiomer is the S-enantiomer of EX-527, EX-527 racemic has an IC50 of 98 nM for SIRT1, in the reference paper, Compound 35S has good potency than 35R, so we speculate that EX-527 S enantiomer is the active form vs R enantiomer.
For research use only. We do not sell to patients.
Chemical Information
| Name | EX-527 S-enantiomer |
|---|---|
| Iupac Chemical Name | (S)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
| Synonyms | Selisistat S-enantiomer ; EX-527 S-enantiomer ; EX527 S-enantiomer ; EX 527 S-enantiomer |
| Molecular Formula | C₁₃H₁₃ClN₂O |
| Molecular Weight | 248.71 |
| Smile | c1cc2c(cc1Cl)c3c([nH]2)[C@H](CCC3)C(=O)N |
| InChiKey | FUZYTVDVLBBXDL-VIFPVBQESA-N |
| InChi | InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)/t9-/m0/s1 |
| CAS Number | 848193-68-0 |
| MDL | MFCD20503073 |
| Related CAS | 848193-69-1 (R-isomer) ; 848193-68-0 (S-isomer) ; 49843-98-3 (racemate) |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid to white solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
| Targets | SIRT1 inhibitor |
|---|---|
| Mechanism | EX-527 S-enantiomer is a potent and selective SIRT1 inhibitor with IC50 of 123 nM |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
