EX-527 R-enantiomer is a negative control of the active form EX-527 S-enantiomer(Speculated for reference); IC50 > 100 uM, e1/e2 can be found in the reference paper.
EX-527 S-enantiomer is the S-enantiomer of EX-527, EX-527 racemic has an IC50 of 98 nM for SIRT1, in the reference paper,
Compound 35S has good potency than 35R, so we speculate that EX-527 S enantiomer is the active form vs R enantiomer. Just for reference!
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