ETC-159
Catalog No: 16060301
CAS Number: 1638250-96-0
Purity: 98% by HPLC
ETC-159, also known as ETC-1922159, is a potent, selective and orally available PORCN inhibitor. ETC-159 blocks the secretion and activity of all Wnts. ETC-159 is remarkably effective in treating RSPO-translocation bearing colorectal cancer (CRC) patient-derived xenografts. Inhibition of Wnt signaling by PORCN inhibition holds promise as differentiation therapy in genetically defined human cancers. Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part by mutations regulating the abundance of their receptors
For research use only. We do not sell to patients.
Chemical Information
| Name | ETC-159 |
|---|---|
| Iupac Chemical Name | 1,3-dimethyl-7-((6-phenylpyridazin-3-yl)glycyl)-3,4,5,7-tetrahydro-1H-purine-2,6-dione |
| Synonyms | ETC 159; ETC-1922159 |
| Molecular Formula | C19H19N7O3 |
| Molecular Weight | 393.407 |
| Smile | CN1C(N(C2N=CN(C2C1=O)C(CNC=1N=NC(=CC1)C1=CC=CC=C1)=O)C)=O |
| InChiKey | COEZTQWWLJCBEC-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H19N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-21-17)15(27)10-20-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9,11,16-17H,10H2,1-2H3,(H,20,23) |
| CAS Number | 1638250-96-0 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
