EN460
EN460 is an endoplasmic reticulum oxidoreductase (ERO1) inhibitor. EN460 showed a dose response effect on the embryos with a dose of 10 μM being significantly lethal during early embryonic development.
For research use only. We do not sell to patients.
Chemical Information
| Name | EN460 |
|---|---|
| Iupac Chemical Name | (Z)-2-chloro-5-(5-oxo-4-((5-phenylfuran-2-yl)methylene)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid |
| Synonyms | EN460; EN-460; EN 460. |
| Molecular Formula | C22H12ClF3N2O4 |
| Molecular Weight | 460.79 |
| Smile | O=C(O)C1=CC(N2N=C(C(F)(F)F)/C(C2=O)=C/C3=CC=C(C4=CC=CC=C4)O3)=CC=C1Cl |
| InChiKey | RSLFQCNAOMQAIH-WJDWOHSUSA-N |
| InChi | InChI=1S/C22H12ClF3N2O4/c23-17-8-6-13(10-15(17)21(30)31)28-20(29)16(19(27-28)22(24,25)26)11-14-7-9-18(32-14)12-4-2-1-3-5-12/h1-11H,(H,30,31)/b16-11- |
| CAS Number | 496807-64-8 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Blais JD, Chin KT, Zito E, Zhang Y, Heldman N, Harding HP, Fass D, Thorpe C, Ron D. A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J Biol Chem. 2010 Jul 2;285(27):20993-1003. doi: 10.1074/jbc.M110.126599. PubMed PMID: 20442408; PubMed Central PMCID: PMC2898301.
2. High-content screen using Zebrafish (Danio rerio) embryos identifies a novel kinase activator and inhibitor
In Press, Accepted Manuscript, Available online 28 February 2017
Werner J. Geldenhuys, Sadie A. Bergeron, Jackie E. Mullins, Rowaa Aljammal, Briah L. Gaasch, Wei-Chi Chen, June Yun, Lori A. Hazlehurst
Chemical Structure
