+86-27-65522453 sales@sun-shinechem.com


Catalog No.: 16071106
Cas No.: 405169-16-6
Purity : 98% by HPLC 
16071106 - Dovitinib | CAS 405169-16-6

Catalog number : 16071106

CAS number : 405169-16-6

Molecular Formula : C24H27FN6O4 

Molecular Weight : 482.51 

Iupac Chemical Name : 4-Amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone 2-hydroxypropanoate 

Smile : OC(C(=O)O)C.NC1=C(C(NC2=CC=CC(=C12)F)=O)C1=NC2=C(N1)C=C(C=C2)N2CCN(CC2)C


PackagingPriceAvailabilityPurityEstimated Shipping Time
Request Bulk Quote Download MSDSTel:+86-27-65522453 | Email:sales@sun-shinechem.com
SynonymsTKI258; TKI-258 
Molecular FormulaC24H27FN6O4 
Molecular Weight482.51 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Coming soon.
 Dovitinib, also known as TKI-258 or CHIR-258, is an orally bioavailable FGFR3 inhibitor, which strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death. In addition, this agent may inhibit other members of the RTK superfamily, including the vascular endothelial growth factor receptor; fibroblast growth factor receptor 1; platelet-derived growth factor receptor type 3; FMS-like tyrosine kinase 3; stem cell factor receptor (c-KIT); and colony-stimulating factor receptor 1; this may result in an additional reduction in cellular proliferation and angiogenesis, and the induction of tumor cell apoptosis. 

405169-16-6 - Request Bulk Quote

405169-16-6 - Request Bulk Quote