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Dolutegravir Sodium

Catalog No: 16122764
CAS Number: 1051375-19-9
Purity: 98% 

Dolutegravir is a HIV integrase inhibitor with IC50 of 2.7 nM.Dolutegravir(S/GSK1349572) inhibits HIV-1 integrase-catalyzed strand transfer with a 50% inhibitory concentration (IC50) of 2.7 nM. S/GSK1349572 inhibits both the HIV integration reaction strand transfer step in vitro and HIV replication in cells with similar potencies. The inhibitor has no effect on total viral DNA synthesis in infected cells but blocks the integration of viral DNA into host DNA with the same potency as its antiviral effect 

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Chemical Information

NameDolutegravir Sodium
Iupac Chemical NameDolutegravir Sodium 
SynonymsGSK-1349572A 
Molecular FormulaC20H19F2N3O5.Na 
Molecular Weight441.36 
SmileFC1=C(CNC(=O)C=2C(C(=C3N(C[C@@H]4OCC[C@H](N4C3=O)C)C2)[O-])=O)C=CC(=C1)F.[Na+]
InChiKeyUGWJRRXTMKRYNK-VSLILLSYSA-M
InChiInChI=1S/C20H19F2N3O5.Na/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22;/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28);/q;+1/p-1/t10-,15+;/m1./s1
CAS Number1051375-19-9
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Ordering Information

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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16122764 - Dolutegravir Sodium | CAS 1051375-19-9

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