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Dimethylenastron

Catalog No.: 16122932
Cas No.: 863774-58-7
Purity : 98% 

Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 (IC50 = 200 nM). Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5. The inhibition of kinesin Eg5 by small molecules such as monastrol is currently evaluated as an approach to develop a novel class of antiproliferative drugs for the treatment of malignant tumours. 

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Chemical Information

NameDimethylenastron
Iupac Chemical NameDimethylenastron 
SynonymsN/A 
Molecular FormulaC16H18N2O2S 
Molecular Weight302.392 
SmileCC1(CC2=C(C(NC(=S)N2)c3cccc(c3)O)C(=O)C1)C
InChiKeyRUOOPLOUUAYNPY-UHFFFAOYSA-N
InChiInChI=1S/C16H18N2O2S/c1-16(2)7-11-13(12(20)8-16)14(18-15(21)17-11)9-4-3-5-10(19)6-9/h3-6,14,19H,7-8H2,1-2H3,(H2,17,18,21)
CAS Number863774-58-7
MDLMFCD09264157
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Ordering Information

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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
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Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16122932 - Dimethylenastron | CAS 863774-58-7

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