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Dimethylenastron

Catalog No.: 16122932
Cas No.: 863774-58-7
Purity : 98% 
16122932 - Dimethylenastron | CAS 863774-58-7

Catalog number : 16122932

CAS number : 863774-58-7

Molecular Formula : C16H18N2O2S 

Molecular Weight : 302.392 

Iupac Chemical Name : Dimethylenastron 

Smile : CC1(CC2=C(C(NC(=S)N2)c3cccc(c3)O)C(=O)C1)C

InChiKey : RUOOPLOUUAYNPY-UHFFFAOYSA-N

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SynonymsN/A 
Molecular FormulaC16H18N2O2S 
Molecular Weight302.392 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCC1(CC2=C(C(NC(=S)N2)c3cccc(c3)O)C(=O)C1)C
InChiKeyRUOOPLOUUAYNPY-UHFFFAOYSA-N
InChiInChI=1S/C16H18N2O2S/c1-16(2)7-11-13(12(20)8-16)14(18-15(21)17-11)9-4-3-5-10(19)6-9/h3-6,14,19H,7-8H2,1-2H3,(H2,17,18,21)
MDLMFCD09264157
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Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 (IC50 = 200 nM). Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5. The inhibition of kinesin Eg5 by small molecules such as monastrol is currently evaluated as an approach to develop a novel class of antiproliferative drugs for the treatment of malignant tumours. 

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