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Difelikefalin

Catalog No.: 21257
Cas No.: 1024828-77-0
Purity : ≧98.0%

Difelikefalin HCl is in stock.

Difelikefalin, also known CR-845; MR-13A-9; MR-13A9, is a novel and potent kappa opioid receptor agonist. CR845 exhibit low P450 CYP inhibition and low penetration into the brain. CR845 may be useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions.

For research use only. We do not sell to patients.

Chemical Information

NameDifelikefalin
Iupac Chemical Name1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-aminopiperidine-4-carboxylic acid
SynonymsCR845 ; CR-845 ; CR 845 ; MR-13A-9 ; MR-13A9 ; Difelikefalin
Molecular FormulaC36H53N7O6
Molecular Weight679.86
SmileO=C(C1(N)CCN(C([C@@H](CCCCN)NC([C@@H](CC(C)C)NC([C@@H](CC2=CC=CC=C2)NC([C@@H](CC3=CC=CC=C3)N)=O)=O)=O)=O)CC1)O
InChiKeyFWMNVWWHGCHHJJ-SKKKGAJSSA-N
InChiInChI=1S/C36H53N7O6/c1-24(2)21-29(32(45)40-28(15-9-10-18-37)34(47)43-19-16-36(39,17-20-43)35(48)49)42-33(46)30(23-26-13-7-4-8-14-26)41-31(44)27(38)22-25-11-5-3-6-12-25/h3-8,11-14,24,27-30H,9-10,15-23,37-39H2,1-2H3,(H,40,45)(H,41,44)(H,42,46)(H,48,49)/t27-,28-,29-,30-/m1/s1
CAS Number1024828-77-0
Related CAS2413256-25-2(HCl); 1024829-44-4 (acetate)

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
Request Bulk Quote Download MSDS Tel : +86-27-65522453   Email : sales@sun-shinechem.com
FormulationSolid powder
Purity≧98.0%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
HandlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Cowan A, Kehner GB, Inan S. Targeting Itch with Ligands Selective for κ Opioid
Receptors. Handb Exp Pharmacol. 2015;226:291-314. doi:
10.1007/978-3-662-44605-8_16. Review. PubMed PMID: 25861786.

(Last update: 4/21/2016).


Chemical Structure

21257 - Difelikefalin | CAS 1024828-77-0

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