Difelikefalin
Catalog No: 21257
CAS Number: 1024828-77-0
Purity: ≧98.0%
Difelikefalin HCl is in stock.
Difelikefalin, also known CR-845; MR-13A-9; MR-13A9, is a novel and potent kappa opioid receptor agonist. CR845 exhibit low P450 CYP inhibition and low penetration into the brain. CR845 may be useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions.
For research use only. We do not sell to patients.
Chemical Information
| Name | Difelikefalin |
|---|---|
| Iupac Chemical Name | 1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-aminopiperidine-4-carboxylic acid |
| Synonyms | CR845 ; CR-845 ; CR 845 ; MR-13A-9 ; MR-13A9 ; Difelikefalin |
| Molecular Formula | C36H53N7O6 |
| Molecular Weight | 679.86 |
| Smile | O=C(C1(N)CCN(C([C@@H](CCCCN)NC([C@@H](CC(C)C)NC([C@@H](CC2=CC=CC=C2)NC([C@@H](CC3=CC=CC=C3)N)=O)=O)=O)=O)CC1)O |
| InChiKey | FWMNVWWHGCHHJJ-SKKKGAJSSA-N |
| InChi | InChI=1S/C36H53N7O6/c1-24(2)21-29(32(45)40-28(15-9-10-18-37)34(47)43-19-16-36(39,17-20-43)35(48)49)42-33(46)30(23-26-13-7-4-8-14-26)41-31(44)27(38)22-25-11-5-3-6-12-25/h3-8,11-14,24,27-30H,9-10,15-23,37-39H2,1-2H3,(H,40,45)(H,41,44)(H,42,46)(H,48,49)/t27-,28-,29-,30-/m1/s1 |
| CAS Number | 1024828-77-0 |
| Related CAS | 2413256-25-2(HCl); 1024829-44-4 (acetate) |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Cowan A, Kehner GB, Inan S. Targeting Itch with Ligands Selective for κ Opioid
Receptors. Handb Exp Pharmacol. 2015;226:291-314. doi:
10.1007/978-3-662-44605-8_16. Review. PubMed PMID: 25861786.
(Last update: 4/21/2016).
Chemical Structure
