Decoglurant
Catalog No: 2071542
CAS Number: 911115-16-7
Purity: 98% Min.
Decoglurant, also known as Ro 4995819, is a negative allosteric modulator of the mGlu2 and mGlu3 receptors which was under development by Roche for the adjunctive treatment of major depressive disorder. Decoglurant progressed as far as phase II clinical trials but was ultimately discontinued from further development due to disappointing efficacy results.
For research use only. We do not sell to patients.
Chemical Information
| Name | Decoglurant |
|---|---|
| Iupac Chemical Name | 5-((7-(trifluoromethyl)-5-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)ethynyl)pyridin-2-amine |
| Synonyms | Ro-4995819; Ro4995819; Ro4995819; Decoglurant. |
| Molecular Formula | C21H11F6N5 |
| Molecular Weight | 447.3444 |
| Smile | NC1=NC=C(C#CC2=C3N=C(C4=CC=C(C(F)(F)F)C=C4)C=C(C(F)(F)F)N3N=C2)C=C1 |
| InChiKey | DMJHZVARRXJSEG-UHFFFAOYSA-N |
| InChi | InChI=1S/C21H11F6N5/c22-20(23,24)15-6-4-13(5-7-15)16-9-17(21(25,26)27)32-19(31-16)14(11-30-32)3-1-12-2-8-18(28)29-10-12/h2,4-11H,(H2,28,29) |
| CAS Number | 911115-16-7 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Javelot H. [Psychopharmacology of anxiety and depression: Historical aspects,
current treatments and perspectives]. Ann Pharm Fr. 2015 Oct 12. pii:
S0003-4509(15)00110-8. doi: 10.1016/j.pharma.2015.09.001. [Epub ahead of print]
Review. French. PubMed PMID: 26472602.
Chemical Structure
