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Daprodustat (Synonyms: GSK1278863)

Catalog No: 112596
CAS Number: 960539-70-2
Purity: 98% Min.

Daprodustat (Synonyms: GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for the treatment of anemia associated with chronic kidney disease.

Daprodustat (GSK1278863), Bulk in stock, contact us by email for Bulk quotation. Kg scale intermediates are also be provided by custom synthesis.

For research use only. We do not sell to patients.

Chemical Information

NameDaprodustat (Synonyms: GSK1278863)
Iupac Chemical Name(1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carbonyl)glycine
SynonymsGSK1278863; GSK 1278863; GSK-1278863; Daprodustat
Molecular FormulaC19H27N3O6
Molecular Weight393.43
SmileC1(CCCCC1)N1C(N(C(C(C1=O)C(=O)NCC(=O)O)=O)C1CCCCC1)=O
InChiKeyRUEYEZADQJCKGV-UHFFFAOYSA-N
InChiInChI=1S/C19H27N3O6/c23-14(24)11-20-16(25)15-17(26)21(12-7-3-1-4-8-12)19(28)22(18(15)27)13-9-5-2-6-10-13/h12-13,15H,1-11H2,(H,20,25)(H,23,24)
CAS Number960539-70-2
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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FormulationOff-white solid to white solid
Purity98% Min.
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO, not in water
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

[1]. Brigandi RA, et al. A Novel Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial. Am J Kidney Dis. 2016 Jun;67(6):861-71

[2]. Hara K, et al. Pharmacokinetics, pharmacodynamics and safety of single, oral doses of GSK1278863, a novel HIF-prolyl hydroxylase inhibitor, in healthy Japanese and Caucasian subjects. Drug Metab Pharmacokinet. 2015 Dec;30(6):410-8


Chemical Structure

112596 - Daprodustat (Synonyms: GSK1278863) | CAS 960539-70-2

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