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Daprodustat (Synonyms: GSK1278863)

Catalog No.: 112596
Cas No.: 960539-70-2
Purity : 98% Min.
112596 - Daprodustat (Synonyms: GSK1278863) | CAS 960539-70-2

Catalog number : 112596

CAS number : 960539-70-2

Molecular Formula : C19H27N3O6

Molecular Weight : 393.43

Iupac Chemical Name : (1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carbonyl)glycine

Smile : C1(CCCCC1)N1C(N(C(C(C1=O)C(=O)NCC(=O)O)=O)C1CCCCC1)=O

InChiKey : RUEYEZADQJCKGV-UHFFFAOYSA-N

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SynonymsGSK1278863; GSK 1278863; GSK-1278863; Daprodustat
Molecular FormulaC19H27N3O6
Molecular Weight393.43
AppearanceOff-white solid to white solid
Purity98% Min.
SolubilitySoluble in DMSO, not in water
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature 
SmileC1(CCCCC1)N1C(N(C(C(C1=O)C(=O)NCC(=O)O)=O)C1CCCCC1)=O
InChiKeyRUEYEZADQJCKGV-UHFFFAOYSA-N
InChiInChI=1S/C19H27N3O6/c23-14(24)11-20-16(25)15-17(26)21(12-7-3-1-4-8-12)19(28)22(18(15)27)13-9-5-2-6-10-13/h12-13,15H,1-11H2,(H,20,25)(H,23,24)
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Daprodustat (Synonyms: GSK1278863) (CAS 960539-70-2)is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for the treatment of anemia associated with chronic kidney disease.

[1]. Brigandi RA, et al. A Novel Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial. Am J Kidney Dis. 2016 Jun;67(6):861-71

[2]. Hara K, et al. Pharmacokinetics, pharmacodynamics and safety of single, oral doses of GSK1278863, a novel HIF-prolyl hydroxylase inhibitor, in healthy Japanese and Caucasian subjects. Drug Metab Pharmacokinet. 2015 Dec;30(6):410-8


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