Dapaconazole
Dapaconazole is an antifungal drug candidate. Phase II trials showed that Dapaconazole tosylate is non-inferior to ketoconazole when used at a dose of 20 mg/day for 28 consecutive days for the treatment of PV. Dapaconazole also demonstrated a good safety profile.
For research use only. We do not sell to patients.
Chemical Information
| Name | Dapaconazole |
|---|---|
| Iupac Chemical Name | 1-(2-(2,4-dichlorophenyl)-2-((4-(trifluoromethyl)benzyl)oxy)ethyl)-1H-imidazole |
| Synonyms | Dapaconazole |
| Molecular Formula | C19H15Cl2F3N2O |
| Molecular Weight | 415.24 |
| Smile | FC(C1=CC=C(COC(C2=CC=C(Cl)C=C2Cl)CN3C=CN=C3)C=C1)(F)F |
| InChiKey | FUAHXHWSMYFWGE-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H15Cl2F3N2O/c20-15-5-6-16(17(21)9-15)18(10-26-8-7-25-12-26)27-11-13-1-3-14(4-2-13)19(22,23)24/h1-9,12,18H,10-11H2 |
| CAS Number | 1269726-67-1 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Gobbato AA, Babadópulos T, Gobbato CA, Ilha Jde O, Gagliano-Jucá T, De Nucci
G. A randomized double-blind, non-inferiority Phase II trial, comparing
dapaconazole tosylate 2% cream with ketoconazole 2% cream in the treatment of
Pityriasis versicolor. Expert Opin Investig Drugs. 2015 Nov;24(11):1399-407. doi:
10.1517/13543784.2015.1083009. Epub 2015 Sep 30. PubMed PMID: 26419668.
2: de Moraes FC, Bittencourt SF, Perissutti E, Frencentese F, Arruda AM, Chen LS,
Babadópulos T, De Nucci G. Quantification of dapaconazole in human plasma using
high-performance liquid chromatography coupled to tandem mass spectrometry:
application to a phase I study. J Chromatogr B Analyt Technol Biomed Life Sci.
2014 May 1;958:102-7. doi: 10.1016/j.jchromb.2014.01.053. Epub 2014 Mar 12.
PubMed PMID: 24705538.
Chemical Structure
