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Danirixin

Catalog No: 16111111
CAS Number: 954126-98-8
Purity: 98% 

Danirixin is a small molecule, non-peptide, high affinity (IC50 for CXCL8 binding = 12.5 nM), selective, and reversible CXCR2 antagonist. 

Danirixin is a small molecule CXCR2 antagonist being evaluated as a potential anti-inflammatory medicine. Danirixin has demonstrated potent antagonism of CXCR2 activity in vitro and anti-inflammatory effects in various preclinical models. Its pharmacologic activity and duration of action following oral administration support its potential use as an oral, anti-inflammatory agent. Danirixin (GSK1325756) is a small, high-affinity, selective and reversible CXCR2 antagonist in development for treatment of chronic obstructive pulmonary disease. Danirixin (GSK1325756) is a small, non-peptide, high-affinity (IC50 for CXCL8 binding 12.5 nM), selective and reversible CXCR2 antagonist. Danirixin has demonstrated potent antagonism of CXCR2 activity, both in vitro and in vivo in preclinical studies. Its oral potency and duration of action support its potential use as an oral, anti-inflammatory agent in the treatment of disorders associated with the accumulation of neutrophils.

 

For research use only. We do not sell to patients.

Chemical Information

NameDanirixin
Iupac Chemical NameDanirixin 
SynonymsGSK1325756; GSK-1325756; GSK 1325756 
Molecular FormulaC19H21ClFN3O4S 
Molecular Weight441.9 
InChiKey
InChi
CAS Number954126-98-8
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16111111 - Danirixin | CAS 954126-98-8

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