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Danicopan

Catalog No.: 2071535
Cas No.: 1903768-17-1
Purity : ≧98.0%

Danicopan, aslo known as ACH-4471 and ACH-0144471, is a highly potent, orally active Factor D inhibitor. Danicopan selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.

For research use only. We do not sell to patients.

Chemical Information

NameDanicopan
Iupac Chemical Name(2S,4R)-1-{[3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol1-yl]acetyl}-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine2-carboxamide
SynonymsDanicopan ; ACH-4471 ; ACH4471 ; ACH 4471 ; ACH-0144471 ; ACH 0144471 ; ACH0144471 ; Danicopan
Molecular Formula C26H23BrFN7O3
Molecular Weight580.4184
SmileO=C([C@H]1N(C(CN2N=C(C(C)=O)C3=C2C=CC(C4=CN=C(C)N=C4)=C3)=O)C[C@H](F)C1)NC5=NC(Br)=CC=C5
InChiKeyPIBARDGJJAGJAJ-NQIIRXRSSA-N
InChi InChI=1S/C26H23BrFN7O3/c1-14(36)25-19-8-16(17-10-29-15(2)30-11-17)6-7-20(19)35(33-25)13-24(37)34-12-18(28)9-21(34)26(38)32-23-5-3-4-22(27)31-23/h3-8,10-11,18,21H,9,12-13H2,1-2H3,(H,31,32,38)/t18-,21+/m1/s1
CAS Number1903768-17-1
Related CAS1903768-17-1

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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FormulationSolid powder
Purity≧98.0%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Konar M, Granoff DM. Eculizumab treatment and impaired opsonophagocytic
killing of meningococci by whole blood from immunized adults. Blood. 2017 Aug
17;130(7):891-899. doi: 10.1182/blood-2017-05-781450. Epub 2017 Jun 19. PubMed
PMID: 28630122; PubMed Central PMCID: PMC5561903.

2: Yuan X, Gavriilaki E, Thanassi JA, Yang G, Baines AC, Podos SD, Huang Y, Huang
M, Brodsky RA. Small-molecule factor D inhibitors selectively block the
alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and
atypical hemolytic uremic syndrome. Haematologica. 2017 Mar;102(3):466-475. doi:
10.3324/haematol.2016.153312. Epub 2016 Nov 3. PubMed PMID: 27810992; PubMed
Central PMCID: PMC5394948.


Chemical Structure

2071535 - Danicopan | CAS 1903768-17-1

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