Danicopan
Danicopan, aslo known as ACH-4471 and ACH-0144471, is a highly potent, orally active Factor D inhibitor. Danicopan selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.
For research use only. We do not sell to patients.
Chemical Information
| Name | Danicopan |
|---|---|
| Iupac Chemical Name | (2S,4R)-1-{[3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol1-yl]acetyl}-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine2-carboxamide |
| Synonyms | Danicopan ; ACH-4471 ; ACH4471 ; ACH 4471 ; ACH-0144471 ; ACH 0144471 ; ACH0144471 ; Danicopan |
| Molecular Formula | C26H23BrFN7O3 |
| Molecular Weight | 580.4184 |
| Smile | O=C([C@H]1N(C(CN2N=C(C(C)=O)C3=C2C=CC(C4=CN=C(C)N=C4)=C3)=O)C[C@H](F)C1)NC5=NC(Br)=CC=C5 |
| InChiKey | PIBARDGJJAGJAJ-NQIIRXRSSA-N |
| InChi | InChI=1S/C26H23BrFN7O3/c1-14(36)25-19-8-16(17-10-29-15(2)30-11-17)6-7-20(19)35(33-25)13-24(37)34-12-18(28)9-21(34)26(38)32-23-5-3-4-22(27)31-23/h3-8,10-11,18,21H,9,12-13H2,1-2H3,(H,31,32,38)/t18-,21+/m1/s1 |
| CAS Number | 1903768-17-1 |
| Related CAS | 1903768-17-1 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Konar M, Granoff DM. Eculizumab treatment and impaired opsonophagocytic
killing of meningococci by whole blood from immunized adults. Blood. 2017 Aug
17;130(7):891-899. doi: 10.1182/blood-2017-05-781450. Epub 2017 Jun 19. PubMed
PMID: 28630122; PubMed Central PMCID: PMC5561903.
2: Yuan X, Gavriilaki E, Thanassi JA, Yang G, Baines AC, Podos SD, Huang Y, Huang
M, Brodsky RA. Small-molecule factor D inhibitors selectively block the
alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and
atypical hemolytic uremic syndrome. Haematologica. 2017 Mar;102(3):466-475. doi:
10.3324/haematol.2016.153312. Epub 2016 Nov 3. PubMed PMID: 27810992; PubMed
Central PMCID: PMC5394948.
Chemical Structure
