DTHIB
DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a Kd of 160 nM. DTHIB physically engages HSF1 and selectively stimulates degradation of nuclear HSF1. DTHIB robustly inhibited the HSF1 cancer gene signature and prostate cancer cell proliferation. In addition, it potently attenuated tumor progression in four therapy-resistant prostate cancer animal models, including an NEPC model, where it caused profound tumor regression.
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Chemical Information
| Name | DTHIB |
|---|---|
| Iupac Chemical Name | 1-(4-chloro-3-nitrophenyl)-3-(4-fluorophenyl)urea |
| Synonyms | DTHIB |
| Molecular Formula | C13H9ClFN3O3 |
| Molecular Weight | 309.6814 |
| Smile | O=C(NC1=CC=C(F)C=C1)NC2=CC=C(Cl)C([N+]([O-])=O)=C2 |
| InChiKey | DWVIOMKFHSRQQM-UHFFFAOYSA-N |
| InChi | InChI=1S/C13H9ClFN3O3/c14-11-6-5-10(7-12(11)18(20)21)17-13(19)16-9-3-1-8(15)2-4-9/h1-7H,(H2,16,17,19) |
| CAS Number | 897326-30-6 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
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| Bulk | Enquiry | Enquiry | Enquiry |
| Purity | 98% Min. |
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Dong B, Jaeger AM, Hughes PF, Loiselle DR, Hauck JS, Fu Y, Haystead TA, Huang J, Thiele DJ. Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1. Sci Transl Med. 2020 Dec 16;12(574):eabb5647. doi: 10.1126/scitranslmed.abb5647. PMID: 33328331.
Chemical Structure
