Cytosporone B
Catalog No.: 16122924
Cas No.: 321661-62-5
Purity : 98%
Catalog number : 16122924
CAS number : 321661-62-5
Molecular Formula : C18H26O5
Molecular Weight : 322.4
Iupac Chemical Name : Cytosporone B
Smile : CCCCCCCC(=O)c1c(cc(cc1O)O)CC(=O)OCC
InChiKey : UVVWQQKSNZLUQA-UHFFFAOYSA-N
| Packaging | Price | Availability | Purity | Estimated Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry |
| Synonyms | N/A |
|---|---|
| Molecular Formula | C18H26O5 |
| Molecular Weight | 322.4 |
| Appearance | crystalline solid |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Storage | 3 years -20ºCpowder |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| Smile | CCCCCCCC(=O)c1c(cc(cc1O)O)CC(=O)OCC |
| InChiKey | UVVWQQKSNZLUQA-UHFFFAOYSA-N |
| InChi | InChI=1S/C18H26O5/c1-3-5-6-7-8-9-15(20)18-13(11-17(22)23-4-2)10-14(19)12-16(18)21/h10,12,19,21H,3-9,11H2,1-2H3 |
| MDL | MFCD12912406 |
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Cytosporone B is the first naturally occurring agonist for nuclear orphan receptor Nur77. The molecule binds with high affinity (IC50=0.278 nM) to the ligand-binding domain of Nur77 and stimulates Nur77-dependent activities. Nur77 is also involved in glucose homeostasis, where it induces genes involved in gluconeogenesis. Csn-B physically binds to Nur77 and activates its transactivational activity and translocation to mitochondria to induce apoptosis. It inhibits cancer cell proliferation and tumor growth.
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