Compound 401 is a synthetic inhibitor of DNA-PK (IC50 = 0.28 M) that also targets mTOR but not PI3K.
Compound 401 shows activity against mTOR (IC50 = 5.3 M) but not p110/p85 PI3K (IC50 > 100 M). Treatment of cells with Compound 401 blocks the phosphorylation of sites modified by mTOR-Raptor and mTOR-Rictor complexes (ribosomal protein S6 kinase 1 Thr389 and Akt Ser473, respectively).
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