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Compound 401

Catalog No.: 611816
Cas No.: 168425-64-7
Purity : 98% 

Compound 401 is a synthetic inhibitor of DNA-PK (IC50 = 0.28 M) that also targets mTOR but not PI3K.

Compound 401 shows activity against mTOR (IC50 = 5.3 M) but not p110/p85 PI3K (IC50 > 100 M). Treatment of cells with Compound 401 blocks the phosphorylation of sites modified by mTOR-Raptor and mTOR-Rictor complexes (ribosomal protein S6 kinase 1 Thr389 and Akt Ser473, respectively).

 

For research use only. We do not sell to patients.

Chemical Information

NameCompound 401
Iupac Chemical NameCompound 401 
SynonymsCompound-401; Compound401 
Molecular FormulaC16H15N3O2 
Molecular Weight281.31 
Smilec1ccc2c(c1)ccn3c2nc(cc3=O)N4CCOCC4
InChiKeyBVRDQVRQVGRNHG-UHFFFAOYSA-N
InChiInChI=1S/C16H15N3O2/c20-15-11-14(18-7-9-21-10-8-18)17-16-13-4-2-1-3-12(13)5-6-19(15)16/h1-6,11H,7-10H2
CAS Number168425-64-7
MDLMFCD10568147
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

611816 - Compound 401 | CAS 168425-64-7

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