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Chrysophanic acid

Catalog No.: 161009017
Cas No.: 481-74-3
Purity : 98% by HPLC 

Chrysophanic acid preferentially blocked proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression. Chrysophanic acid treatment in SNU-C5 cells inhibited EGF-induced phosphorylation of EGFR and suppressed activation of downstream signaling molecules, such as AKT, extracellular signal-regulated kinase (ERK) and the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic acid (80 and 120 Âm) significantly blocked cell proliferation when combined with the mTOR inhibitor, rapamycin. These findings offer the first evidence of anticancer activity for chrysophanic acid via EGFR/mTOR mediated signaling transduction pathway. 

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Chemical Information

NameChrysophanic acid
Iupac Chemical Name1,8-dihydroxy-3-methylanthracene-9,10-dione 
SynonymsChrysophanol; Chrysophanic acid 
Molecular FormulaC15H10O4 
Molecular Weight254.2375 
SmileOC1=CC(=CC=2C(C3=CC=CC(=C3C(C12)=O)O)=O)C
InChiKeyLQGUBLBATBMXHT-UHFFFAOYSA-N
InChiInChI=1S/C15H10O4/c1-7-5-9-13(11(17)6-7)15(19)12-8(14(9)18)3-2-4-10(12)16/h2-6,16-17H,1H3
CAS Number481-74-3
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Ordering Information

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FormulationSolid powder 
Purity98% by HPLC 
Storage-20 ºC for 3 years 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
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Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

161009017 - Chrysophanic acid | CAS 481-74-3

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