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Chrysophanic acid

Catalog No.: 161009017
Cas No.: 481-74-3
Purity : 98% by HPLC 
161009017 - Chrysophanic acid | CAS 481-74-3

Catalog number : 161009017

CAS number : 481-74-3

Molecular Formula : C15H10O4 

Molecular Weight : 254.2375 

Iupac Chemical Name : 1,8-dihydroxy-3-methylanthracene-9,10-dione 

Smile : OC1=CC(=CC=2C(C3=CC=CC(=C3C(C12)=O)O)=O)C

InChiKey : LQGUBLBATBMXHT-UHFFFAOYSA-N

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SynonymsChrysophanol; Chrysophanic acid 
Molecular FormulaC15H10O4 
Molecular Weight254.2375 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileOC1=CC(=CC=2C(C3=CC=CC(=C3C(C12)=O)O)=O)C
InChiKeyLQGUBLBATBMXHT-UHFFFAOYSA-N
InChiInChI=1S/C15H10O4/c1-7-5-9-13(11(17)6-7)15(19)12-8(14(9)18)3-2-4-10(12)16/h2-6,16-17H,1H3
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Chrysophanic acid preferentially blocked proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression. Chrysophanic acid treatment in SNU-C5 cells inhibited EGF-induced phosphorylation of EGFR and suppressed activation of downstream signaling molecules, such as AKT, extracellular signal-regulated kinase (ERK) and the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic acid (80 and 120 Âm) significantly blocked cell proliferation when combined with the mTOR inhibitor, rapamycin. These findings offer the first evidence of anticancer activity for chrysophanic acid via EGFR/mTOR mediated signaling transduction pathway. 

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