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Cerdulatinib (PRT062070)

Catalog No: 16122917
CAS Number: 1198300-79-6
Purity: 98% 

Cerdulatinib, also known as PRT2070 and PRT062070, is a n ovel, oral, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Cerdulatinib preferentially inhibited JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in various cell types. IL2 mediated STAT5 Y694 was inhibited with an IC50 of 0.27M, while IL4 mediated signaling to STAT6 Y641 and functional responses in B cells and monocytes, namely CD69, CD25, and CD23 up-regulation, were inhibited with IC50Âs within the range of 0.11M to 0.57M. It is currently being studied in patients with genetically-defined hematologic cancers, as well as for patients who have failed therapy due to relapse or acquired mutations. 

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Chemical Information

NameCerdulatinib (PRT062070)
Iupac Chemical NameCerdulatinib (PRT062070) 
SynonymsPRT2070; PRT-2070; PRT 2070; PRT062070; PRT 062070; PRT-062070 
Molecular FormulaC20H27N7O3S 
Molecular Weight445.54 
InChiKey
InChi
CAS Number1198300-79-6
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16122917 - Cerdulatinib (PRT062070) | CAS 1198300-79-6

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