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Cerdulatinib (PRT062070)

Catalog No.: 16122917
Cas No.: 1198300-79-6
Purity : 98% 
16122917 - Cerdulatinib (PRT062070) | CAS 1198300-79-6

Catalog number : 16122917

CAS number : 1198300-79-6

Molecular Formula : C20H27N7O3S 

Molecular Weight : 445.54 

Iupac Chemical Name : Cerdulatinib (PRT062070) 

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SynonymsPRT2070; PRT-2070; PRT 2070; PRT062070; PRT 062070; PRT-062070 
Molecular FormulaC20H27N7O3S 
Molecular Weight445.54 
Appearancecrystalline solid 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
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Cerdulatinib, also known as PRT2070 and PRT062070, is a n ovel, oral, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Cerdulatinib preferentially inhibited JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in various cell types. IL2 mediated STAT5 Y694 was inhibited with an IC50 of 0.27M, while IL4 mediated signaling to STAT6 Y641 and functional responses in B cells and monocytes, namely CD69, CD25, and CD23 up-regulation, were inhibited with IC50Âs within the range of 0.11M to 0.57M. It is currently being studied in patients with genetically-defined hematologic cancers, as well as for patients who have failed therapy due to relapse or acquired mutations. 

1198300-79-6 - Request Bulk Quote

1198300-79-6 - Request Bulk Quote