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Capivasertib ( AZD5363 )

Catalog No: 71805
CAS Number: 1143532-39-1
Purity: 98%

Capivasertib is a novel pyrrolopyrimidine derivative, and an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. Capivasertib binds to and inhibits all AKT isoforms. Inhibition of AKT prevents the phosphorylation of AKT substrates that mediate cellular processes, such as cell division, apoptosis, and glucose and fatty acid metabolism. A wide range of solid and hematological malignancies show dysregulated PI3K/AKT/mTOR signaling due to mutations in multiple signaling components. By targeting AKT, the key node in the PIK3/AKT signaling network, this agent may be used as monotherapy or combination therapy for a variety of human cancers.

For research use only. We do not sell to patients.

Chemical Information

NameCapivasertib ( AZD5363 )
Iupac Chemical Name4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide 
SynonymsAZD5363 ; AZD-5363 ; AZD 5363 ; Capivasertib
Molecular FormulaC21H25ClN6O2 
Molecular Weight428.92 
CAS Number1143532-39-1
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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FormulationOff-white solid 
Storage3 years -20ºCpowder 6 months-80ºCin solvent 
SolubilitySoluble in DMSO 
Shipping ConditionShipped under ambient temperature 
HS Code
TargetsAKT Kinase Inhibitor
Cell study
Animal study
Clinical study

[1]. Davies BR, et al. Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. Mol Cancer Ther. 2012 Apr;11(4):873-87.

Chemical Structure

71805 - Capivasertib ( AZD5363 ) | CAS 1143532-39-1

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